Journal article
Visually Identified Tau 18F-MK6240 PET Patterns in Symptomatic Alzheimer's Disease
N Krishnadas, K Huang, SA Schultz, V Doré, P Bourgeat, AMY Goh, F Lamb, S Bozinovski, SC Burnham, JS Robertson, SM Laws, P Maruff, CL Masters, VL Villemagne, CC Rowe
Journal of Alzheimer S Disease | IOS PRESS | Published : 2022
DOI: 10.3233/JAD-215558
Abstract
Background: In Alzheimer's disease, heterogeneity has been observed in the postmortem distribution of tau neurofibrillary tangles. Visualizing the topography of tau in vivo may facilitate clinical trials and clinical practice. Objective: This study aimed to investigate whether tau distribution patterns that are limited to mesial temporal lobe (MTL)/limbic regions, and those that spare MTL regions, can be visually identified using 18F-MK6240, and whether these patterns are associated with different demographic and cognitive profiles. Methods: Tau 18F-MK6240 PET images of 151 amyloid-β positive participants with mild cognitive impairment (MCI) and dementia were visually rated as: tau negative,..
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Awarded by Commonwealth Scientific and Industrial Research Organisation
Funding Acknowledgements
This work was supported by the NHMRC (National Health and Medical Research Council) [grant numbers APP1132604, APP1140853, APP1152623]. NKwas supported by a cofunded PhD scholarship from Australian Rotary Health/Estate of Bartolina Peluso. The data used in the preparation of this article was obtained from the Australian Imaging Biomarkers and Lifestyle flagship study of aging (AIBL), funded by the Commonwealth Scientific and Industrial Research Organization (CSIRO), National Health and Medical Research Council (NHMRC), and participating institutions. AIBL researchers are listed at www.aibl.csiro.au.The authors would like to acknowledge the Brain Research Institute. The authors thank all participants who took part in the study, as well as their families.